Arsene Wenger has handed Reiss Nelson his full Premier League debut as Arsenal face Southampton at the Emirates.
The academy graduate will join Pierre-Emerick Aubameyang, Alex Iwobi and Danny Welbeck in attack as the Gunners look to continue their return to form.
Henrikh Mkhitaryan limped out of Thursday’s Europa League win over CSKA Moscow with a knee problem and does not start.
Goalkeeper David Ospina (ankle) is also sidelined, as is long-term absentee Santi Cazorla (Achilles), but Aubameyang returns having been cup-tied in Europe.
Southampton’s Mario Lemina failed a late fitness test, with Pierre-Emile Hojbjerg, Oriol Romeu backing up the midfield two.
The Gabonese defensive midfielder is yet to fully recover from a virus and despite returning to training on Friday and has not been passed fit.
Arsenal: Cech, Bellerin, Chambers, Mustafi, Kolasinac, Elneny, Xhaka, Iwobi, Nelson, Welbeck, Aubameyang
Subs: Macey, Holding, Monreal, Wilshere, Ozil, Lacazette, Nketiah
Southampton: McCarthy, Cedric, Stephens, Hoedt, Yoshida, Bertrand, Romeu, Tadic, Hojbjerg, Ward-Prowse, Long
Subs: Forster, Pied, Redmond, Sims, Boufal, Austin, Gabbiadini
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